I am using one now. I mic'd the speaker (v30) really good, hit it with a decent mic pre. I'm playing a Mesa Rectifier with the tube screamer. I can not get it to sound pro at all! I use my 4x12 with v30's it kills! And that thing is really loud!
And maybe for a solo the guitar could pan towards center sometimes like the guy walked to the center of the room, mostly I just leave leads panned hard too, i guess it just depends on on what kind of feel your going for.
I pan hard right and hard left. Guitar one at 100% and 70% and Guitar 2 is the opposite. Of course you can pan guitar 1's reverb on guitars 2 side and vice versa. Makes it sound like your in the room watching them jam. Just don't over do it.