The combo's sound better than the heads in stock form also because the power tubes are biased much hotter in the combos, for whatever reason. When my 6505+ was stock, I measured the bias at about 17mA from the factory. That's COLD, lol. The combos (from what I read) generally sit closer to 27mA.
After a resistor swap and a little tittie-twisting on the bias control knob, I have mine pulling about 40mA right now and it sounded MUCH better than before, a lot of that hissy shit completely vanished.
(What you're hearing is an absence of crossover distortion, which is why it sounds more clear)
As for "You can pull any tube you want" - the point is that, when you see how it's wired, you learn that the two left tubes and the two right tubes are fed through independent circuits. When one "side" has an "upward" swing in amplitude, the opposite side has a "downward" swing, and it's partially the job of the Phase Inverter to maintain that balance. When you yank both left tubes out, that whole process stops and the tone will change, likely for the worse. (At least from what I understand)
*EDIT* upon rereading, I realized you said 'any tube on either side as long as you have one one on each side', lol sorry. *facepalm*