I'd say that if your heading for a plucked guitar, you wanna have the tone that distinguishes every pluck, every note clearly, no blur, no standing wave. If after wards you want more sustain, the compressor will give more sustain so you'll get a decent amout of sustain insted of a standing wave. Then you wanna make sure that the bass as room to breathe in the 400 hz to 500 hz zone so that tone you achieved really stands out in the mid section. Then you can raise around 2khz if you miss definition, but don't overdo it or the mix will start sounding aggresive. If your heading for a picked bass, you still wanna achieve a tone that makes every hit on the strings defined and clear. Then you wanna make sure the bass as room to breathe around 1.5 khz and in a certain bass section higher than 50 hz. You can increase defintion by raising the 4 khz zone or the 1.5 khz, but still without overdoing it or it will simply raise the notes in an aggresive way. Good luck!
