I can't do vibrato well with anything other than 9-42. I guess call me a pussy too, but I just seriously can't get 10-46 to work. The vibrato and 5 semi tone bends I do are just painful with that string gauge.
Although these days I use 7 strings, I was never a down tuned type of guy.
Drop D yes, but I never did the whole C standard thing or whatever.
Works for some guitarists/bands, but Opeth and Sylosis have proved you can be HEAVY AS FUCK in E standard. If anything, the tightness that not down tuning provides makes it sound even heavier sometimes.
I just use B standard with my 7 strings (9-42+59 gauge strings), so I can still play along to Opeth, Megadeth, Metallica, Foo Fighters, whatever really.
The low B is plenty low. Some guitarists like to do this whole crazy G#, even G standard on their 7 strings, but it's not for me.