Get the Rock Classic Model, Put it through the matching 8x10 cab, use a U47 close up with about 20% room. Put the bass driver on if you need more drive than the amp can give you. Set the EQ on the amp as you would with a basic high gain guitar tone, bass 6/7 mid 4/5 bass 6/7.
That's what I use and it sounds great in the mix. I use the same set-up on Ampeg SVX though and have to say that it slay's the POD.