I have been looking into this too. Not only for final tracks but even tracking full bands without isolation rooms.
To me isolation cabs have that boxy weird shittiness. However, the Silent Sister does not but $$$. So to me that would be the "ultimate" option. But it also isn't silent and with the venting causes a lot of low-end rumble in the room. However, lots of people love the tone and feel like they get the punch and dynamics they want.
On the cheap, I have been toying with the idea of getting a Jet City Iso cab and modding it with a labyrinth air chamber down the side or something.
Also basically the other option is load boxes and IR's however you achieve that. Either with the TwoNotes box or in the DAW, the results should be very similar if not identical with the same IR. But IR's have their own weirdness even though some claim they can't hear a difference. To me they don't have the low-end punch and have strange static resonances and I just can never get them to sound as good as mic'd cab. Even making my own and A/Bing the IR sounds 2D and has some weird upper midrange-ness that I don't like. But of course many dudes get some killer tones out of them.
In my head, the least amount of compromise would be the silent sister. Everything is real and the demos I have heard sound pretty good to me. But to many the IR option isn't too far behind if at all.
This is all assuming you are dead set on using your tube amps, and for good reason! So far my favorite has been the Kemper. Dial in a tone with a mic, profile it... use it for all the tracking... profit. At least then you are only pissing off your neighbors for an hour or so. But even with the Kemper, I nearly always start with an amp tone first.