Jeff is dead on! I even had a client of mine ask why i'd changed his fret spacing because the low f, and f# were a little off from his open E. The funny thing is you can't change the relation between these notes at this range by neck relief or bridge placement. The guitar frets are placed by mathmatical formula, not by note recognition. Therefore the relation of space between frets has been determined by a formula, not by cents of a note. The neck relief plays a part in this but it is sooooo minimal that I BEG you to tell me the difference intoanation wise without a real accurate tuner, and even then maybe not. I actualy experimented with a real accurate tuner, an old guitar neck, a piece of wood with a radius cut out to match the radius of my neck. a rubber mallot, and a few beers. I began to pound every fret into close to perfect tuning by bumping them sharp flat or a combination of both and I drove myself nuts! Moral of this story, get a reputable guitar and have it checked by a tech or luthier and have them make the proper adjustments dependng on string gauge and tuning. If you find the right tech he'll help you by explaining the adjustments made and work with you to make "it" right, and you'll have a wealth of information on how to set up your own guitar to "your specs." Ask around I am sure their is someone real near you that can get you on the right path to making your guitar right.