THE OMEGA MAN (1971): Directed by Boris Sagal, starring Charlton Heston
Classic movie based on the novel, I am Legend. Here's a description from DVD empire:
Welcome to the future. Biological war has decimated life on Earth. Los Angeles is a windswept ghost town where Robert Neville tools his convertible through sunlit streets foraging for supplies. And makes damn sure he gets undercover before sundown, when other "inhabitants" emerge.
The Omega Man adapts Richard Matheson's novel I Am Legend into a high-impact, high-tension saga of[font=verdana, arial, sans-serif][size=-1]i[/size][/font]a fate not far removed from reality. Charlton Heston is Neville, fending off attacks by The Family, sinister neopeople spawned by the plague. He also becomes a man with a mission after meeting Lisa (Rosalind Cash), another uninfected survivor - and guardian of some healthy children representing our species' hope.
Since 1971, this movie has never ever been considered a Zombie flick, and for the rest of time, neither will 28 Days Later.