I wrote an acoustic ballad on my electric guitar which required a lot of barring (spelling?) and big finger stretches.
It was easy to do when recording a rough take on my electric guitar with thin strings and low action.
When I picked up my acoustic, it was really fucking hard to make all the notes ring out cleanly so I made two mono tracks grouped to an additional group track with a compressor and a touch of reverb. I played the bass parts on one track and the additional notes on another track and it sounds like it's one perfect take of a single track. The key to make it authentic is to hold the awkward chord and play the comfortable notes and pretend you're picking the awkward notes so nothing rings out unnaturally when the fingering changes. The best analogy would be making sure your virtual drums doesn't haver a hi-hat on the quarter notes when there's a fast 16th note tom fill.
I know this isn't exactly what you're asking, but of course what you're suggesting would work. It's called orchestration.