I find getting the brightness is the hardest part of getting a good POD tone. I'm really happy with the mid range of my tone, whereas getting a good brightness without it becoming too bright is where I'm struggling. However that might be because I need better pickups, I only use the stock Ibanez pickups right now.
Also, Sean in Silence, interesting you high pass at only 60Hz, I would have figured 100 Hz would be much safer and would leave more room for the bass.
Another point, is that I avoid using the Screamer and prefer the Line 6 Boost+EQ, because it gives you more tone shaping options, plus it just sounds better IMO.