in short, the bias is what controls how much voltage runs thru the tubes...on most amps this is adjustable, meaning you have to have the amp biased each time you replace the tubes (this ensures that your tubes are getting the proper voltage) the downside to this is that it can be a pain, and you have to take the amp to a tech genereally for a tube change...the upside is that you get the most tone out of the amp/tubes; as said above, if you don't know how to bias an amp, DON'T TRY IT!!! it could be dangerous for you, and harmful to your gear
an amp like the 5150 is what's called fixed bias, it has no adjustment to control the voltage; the level is set really low, so any tubes you install will run properly...the upside here is that you don't have to worry about biasing the amp everytime you change tubes, the downside is that you don't really get the best tone your amp COULD be getting because the tubes aren't running at the optimal setting
5150's (in addition to their killer tone) are popular touring amps because they're built like tanks (believe me they can take A LOT of abuse) and you don't have to worry about finding a tech if you need to swap tubes