Hmm, cable capacitance usually rolls off the highs and adds a resonant bump in the 2k to 6k range, which will disappear with this buffer. I'm thinking that will change the distortion tone from smoother to hairier/fizzier.
I heard Hendrix wanted the curliest longest cheapest guitar cable he could find to get max capacitance and that cocked-wah smooth lead tone, so yeah I can see this buffer not being suitable for everyone.
But if it's your thing, the DI function, frequency range, and extreme low noise is pretty amazing. I wouldn't mind installing this in my bass since my previous preamp (which I took out) hissed too much.