Probably you'll have to lower the volume of lead and increase it a bit around 1khz. If this is not compatible with your mix, maybe it's the best to duck rhythm guitars a bit, compress your lead guitar and kill a few dbs on it, so it doesn't get harsh. It's probably not only the problem of volume, but the problem of tone, playing, pickup, etc, but it should work alright if it is a bit down in the mix. The neck pickup is usually way more consistent for leads, and thus way easier to mix in, so if you have to deal with a harsh bridge pickup and pretty harsh playing, there is no MUCH that you can do, unfortunately.