cobhc
Amiga Enthusiast
Devin Townsend can (see 6:40 onwards)
http://www.youtube.com/watch?v=xLb7sj8ErS0
Honestly, I totally agree with him - once the low strings become too thick, then I find it sounds too muffled, and it's really the pinch harmonic silliness that's the deal breaker for me (I find it so much easier to get a good harmonic and vibrato on a .52 than even a .54, to say nothing about anything thicker). Here's a vid of me playing, I wouldn't say I'm a slouch or a wimpy picker! (and once again, neither is Devin)
http://www.youtube.com/watch?v=ao-z8XQTa2Y&feature=channel_page
I get what you're driving at, but I wouldn't call you a very strong picker, and Devin is in Open C tuning, not C.