The only reason I don't like Bolt On necks nearly as much as I do Neck Thru is because almost every singe Bolt On I've ever played with the exception of my 2 Ibanez Axes has a neck joint that sticks out and gets in the way of my hand. That's why I can't stand playing alot of Fenders or Jacksons. The High Frets are integral for my playing, and if I can't get all the way up there without much interference, then it makes it much harder for me to play it. On almost every Neck Thru I've played, one of the things I loved most was that the neck joint was barely even noticable. That's the only reason I like Neck-Thrus better. The Sustain is a bonus.
Also, I've been working on a design for a guitar recently in which the truss Rod is actually adjusted from the bottom of the body as opposed to the top of the neck. It would have to be a Neck Thru of course, and one of the biggest problems I've encountered was how to get it around the electronics.