So we'll just say that unlike some other DAWs, REAPER will support almost any existing audio interface, even interfaces manufactured by companies whose software does not allow you to use any other hardware interface.
I always hated the name Pro Tools. It's the worst name one can possibly even imagine for a software which intends to give tools to work with for professionals. And this has NOTHING to do with this thread so if you read it, HAHA! *points* (Note this rant is only about the name, I haven't even tried the software itself.)
Reaper is quite a gay name too to be honest, but still... it's cheap as fuck and does all it's supposed to do so what the fuck