power tubes should be taken in pairs.
I've done it with my laney.
4 tubes = 100W on the laney
I took out the 2 inner tubes (you can take the 2 outer ones) = 50W
there isn't much of a volume difference, Its just that the amp reacts differently because of the early break up.
The clean distorts sooner and the drive channels saturate sooner.
to do this safely, You have to adjust the impedance on the amp.
BEFORE:
100W -> amp @ 16 ohms connected to cab @ 16 ohms
NOW (power tubes removed):
50W -> amp @ 8 ohms connected to cab @ 16 ohms
For you mesa F-50 I don't know If its possible to do that.
If it has only 2 power tubes, taking out just one might engage the protection circuit and blowing the protection fuse.
Inform yourself with Mesa first.
take care
LG