Start with everything on 12' o clock, and adjust depending on what you want to hear. It sounds basic, but that is really all there is to it.
One thing I like to do though when working with impulses, is to add an EQ after the impulse and add a pretty big high shelf filter, to add alot of high end to the tone. I always feel my tones get way to dark without it, and it also helps with getting the most from your distorsion.