I use Reaper, which has an excellent slip editing design. First and foremost, good technique and playing is your best friend.
If you want to make spliced, quick edits to get a tight sound with a poor player or an unfamiliar song, you have to record DI guitars. This makes it easier to find the notes (and their attack) which you can cut and align to the grid/drums. I generally don't overuse this, I used it a few times here for time's sake. It's especially useful when you're recording as you write, which doesn't give you much time to practice.
Sometimes you can't be bothered doing 15 takes to get a new riff in tightly. You may have a take that is 95% perfect but has one or two notes out. If these notes repeat, you can copy and paste earlier repetitions in the same way you cut and paste different takes.
Ultimately though, it's about getting tight takes in the first place and tracking well*. Fixing takes with slip editing is no different than 'fixing it in the mix'.
*By this I don't mean that tracking very slowly, even note by note is a bad thing. I mean to say that going back over poorly played parts and fixing them using slip editing is a bad idea.
One interesting thing I find is that musicians always generally land just ahead of or just behind the beat. As someone who lands just ahead of the beat, sometimes the initial attack of the first note I'm tracking can be lost without a touch of slip editing. Bringing that attack in makes a fairly large difference.
Hopefully my rambling will have helped somewhere.
And what did you use for the guitar tones?
