If you take the time to learn all the Reaper macro commands and extensions (including 3rd party extensions), you realize that Reaper is freakin' awesome. I bet most of the features in Cubase are doable in Reaper; you just have to find the command(s), create your own personal macro, then put it where you want it. Put a button in the main button bank, or put it in your right-click menu, or assign a keyboard shortcut, or whatever.
For example: I like Cubase's audio editor, and Reaper doesn't have one; in Reaper, you would typically just do your audio editing right in the main project window. But I started looking at all the Reaper commands available, and I created my own audio editor that's better for me than the one in Cubase. With a little reading and a little creative thought, you can create your own personal tools that are unlike anything anyone else in the world uses.
Personally, I don't like keyboard shortcuts so much. I mostly prefer to use the mouse for everything, so all the commands I use a lot, I have assigned to mouse gestures (which duplicate keyboard shortcuts) or mouse buttons.
Now, this next thing I'm going to say is going to make me look like a dope: I actually use Cubase, not Reaper. For one reason: Reaper still hasn't implemented the ability to edit drum maps within the MIDI/drum editor. Within Cubase's drum editor, I can grab drum pieces and drag them wherever I want them, then save that drum map right there within Cubase. I have all my hi-hats together, all my snares, etc. This just makes a HUGE difference to me when programming drums, and it's the only thing keeping me in the Cubase camp.
For a while, I was recording in Reaper and programming drums in Cubase, but I really don't like to switch back and forth, so Reaper hit the shelf. So like Joey Sturgis, one more feature and I will move to Reaper.