Cut what sounds like shit. Good idea with the narrow Q boosting, but I'd boost it more. A/B mixes, and find what is characteristically different. You'd be surprised how much of a difference pickups make when it comes to amp sims though. Also, EQ the shit out of stuff. Amp sims don't respond the same as a regular amp when you turn the dials.
But honestly, post EQ'ing out the shit, and possibly the harmonics of the shit is a good idea. Don't be afraid to boost man. Seriously, it's really not that big of a deal to boost ITB. I know a lot of people seem to make it a big deal, but I know a friend of mine who does really weird boosts and cuts in guitars (big boosts, at that) and they still sound better than almost all of the productions on here. Just use your ears man. I think you've been reading the forums more than working with recording, and that can prove to be a bad thing. These forums are a great information source, but everyone has a different way of doing things - so take every bit of information with a grain of salt.
Also, compression is key to add punch man.
And don't just blindly listen to people's advice with things. I know everyone talks so much about C4 and it's awesome wonders, but honestly, my guitars have been sounding better ever since I stopped using C4 man.
Trust your ears, not forums.
And also, if you don't have a treated room, getting a good hold on the high end of guitars will prove challenging.