I don't understand your question bro.
If you meant an amp sim with another amp sim on the same channel in series...then obviously the answer would be no.
If you meant using both a LePou sim with TSE X50 in a project together (on separate tracks)...probably depends on the song but I'm sure you could find a decent combo that would work.
And then of course there's LeCab which, yeah obviously will work with the X50.
I've read here specifically that some guys use the SoloC as a boost 'pedal' instead of a screamer...so there's also that.