I left mine on mostly for years...eventually it blew a power supply, although I can't say if that was a factor. Now I leave it on all the time in winter to heat the studio, and turn it off as much as I can in summer...it generates a lot of heat! Leaving it running while away in hot conditions could be risking fire I reckon.
I used to leave electronic gear on too believing it lasted longer, Danni from over at the Reaper forums dispelled that myth for me. She worked as a repair tech for years, and was adamant it was LENGTH OF TIME running that shortens the life of components and causes eventual failure.
Specifically, she said leaving gear running wears out resistors etc, and especially dries out electrolytic caps over time, which also happens in old amps. These then usually fail at startup under load, but they have degraded over time, and startup is the most stressful time for them.
I wish I could find that link because it was quite convincing, plenty of tech heads contributed, and Danni gave lots of real world failure examples to back up her view.
OT, leaving your computer running nonstop with a fan is asking for the same thing, especially if you don't vacuum the dust out at intervals. I still leave mine on mostly for convenience, but it's something to consider when it's getting older.