Read on the other post you're a scientist, what kind? I'm a microbiology major so I love that stuff. BTW I almost pissed myself when I saw that kermit thing



remington69 said:I do research on the BRCA1 gene. It's a combination of molecular and cell biology. Basically, we're trying to knockdown BRCA1 in mammary tissue via siRNA. Our hypothesis is that BRCA1 has a role in double strand break repair (as well as cell cycle control). We should be submitting a paper by mid-July to either Science or PNAS (hopefully!)
I graduated the University of Florida (go gators!) with a B.S. in Microbiology and Cell Science with a minor in chemistry. Got rejected from med school with a 3.5 GPA, sucks being a white male. Is the gene you're working on involved in DNA repair during replication? That's great you get to work on projects like that, it's people like you that help advance mankind!remington69 said:I do research on the BRCA1 gene. It's a combination of molecular and cell biology. Basically, we're trying to knockdown BRCA1 in mammary tissue via siRNA. Our hypothesis is that BRCA1 has a role in double strand break repair (as well as cell cycle control). We should be submitting a paper by mid-July to either Science or PNAS (hopefully!).
What kind of micro are you into?
remington69 said:I do research on the BRCA1 gene. It's a combination of molecular and cell biology. Basically, we're trying to knockdown BRCA1 in mammary tissue via siRNA. Our hypothesis is that BRCA1 has a role in double strand break repair (as well as cell cycle control). We should be submitting a paper by mid-July to either Science or PNAS (hopefully!).
What kind of micro are you into?
You're doing great work, if you can isolate the direct result of the mutation of the gene you're working on and treat it, you can pretty much eliminate breast cancer altogether. Still though the primary cause of the mutation is very much hereditary, as you said, but is also very much affected by environmental means (smoking, sun exposure, etc.) That's why I first thought mutations due to errors during DNA relication, which as you know occur regularly as each cell replicates. Maybe a compromise in the enzyme DNA lygase? Who knows, but you're working hard to figure it out, you're awesome! Keep it up, keep me informed of what you find.remington69 said:sufferer: That sucks about med school. That's why I never even attempted to apply. As for BRCA1, it's more involved in DNA repair do to damage. However, I've read some papers that have theorized that it's involved in replication repair too.
strik9: No. We use cells that come from actual mammary tissue. There's a nation-wide cell depository that we get them from. Besides, being in Illinois and at a publically funded institution, we wouldn't be able to touch stem cells with a ten foot pole.
mrthrax: Basically, hereditary form of breast cancer occurs when there is a mutation in the BRCA1 gene. That's all what people pretty much know about the process. Our lab (along with others throughout the world) is trying to find out what exactly happens in the body when that gene is mutated and how a tumor arises from that. The information then could be used to help treat tumors early on.
DarbysDad:![]()
Yeah thank God I'm not in charge of this kind of stuff! I'm barely smart enough to be on the internet, let alone try to cure diseases!DarbysDad said:Glad there's folks like Remington doing this work - you all![]()