seriously, when you analyze spiderman's villains, there just HAS to be camp. it would be fucking hard to make a dark spiderman movie. especially with the audience that's contributed to building the momentum so far.
carnage can't be an option. the studio either wouldn't let it, or the fans would tear the adaptation to shreds. right now, the only viable villain i can see is lizard. vulture, shocker, electro, rhino, scorpion? kiiind of pushing things camp-wise. kraven could be possible, but they'd go all over the place with his costume. mysterio and chameleon would be a smart move, too.
all things considered, a sinister six movie could work.