Well the whole idea behind the NS10's (maybe not so much Yamaha's intention, but rather what engineers have found them useful for, lol) is that if you can make something sound good on them, it'll sound good on anything.
I'm not quite sure of which way, or method, would be best suited for implementing these in a studio. Either by having them as mains, and using them from the beginning to get from basic sounds to final mix and master, or use something else to get your foundation and have the NS-10's for checking the mix, or just using them for a final mix. I can't see any advantage or disadvantage going either route, as both ways seem to end in the same result: your final mix going through the Yama's.
Personally I think the Yamaha's are probably the single best monitors to start on simply because they make you work your ass off. You know if it sounds wrong no matter what. And you'll know exactly when something sounds right. However, on a more "true" pair of monitors, such as the Event TR-8's or KRK RP-8's, you can hear everything much easier and be able to make adjustments quickly, making it harder for you to really develop an ear, or rather, a very fine ear anyway. With the NS-10's, you have to really listen, it's basically something I like to think of as a more dedicated way of mixing. In perspective, other monitors on the market that are more "true" reflect the adverse term, in other words, lazy monitoring. If you want to make your life very easy, get something that's "true", such as the Events or KRK's, if you want to really learn some valuable stuff that will stick with you for life, go for the NS-10's, and coincidentally, have amazing mixes that really make your hard work pay off.
That's just my .02 cents though. Cheers.
~006
