what seems to work well for me is to just minimal distortion. if you are playing in a live situation with two guitars especially, you are not going to need much distortion to get a good crunch. too much will sound muddy, harsh, and your notes won't cunt through. all you need is a good crunch. i also recomend a dark guitar tone (especially for the clean tones), and don't scoop your mids. As far as distortion, try to find a smooth one. harsh and raw isn't what you want unless you are going for an orchid/morningrise tone.