They're sample aligned if you use them through kontakt (ie, programming your own drums). If you're just using drumagog to trigger the Z4/Z5 then I don't think they are. I always manually program the kick, snare, and toms as well as velocities. I for the life of me can't get drumagog to ever trigger properly with the type of music I'm working with. One of these day's I'll have to sit and mess with it some more. You've probably heard it a million times but when in doubt, just use your ears, if it's sounds good not nudged, leave it, if it sounds better nudged, then go with that.