Interesting. Not to say that the same settings don't work...I've just always found that the leads are much easier to work with and they sound better in the mix to start with when the settings aren't the same. To me it's like having just another "rhythm" guitar since the settings would be the same, if it's leads it should have a different sound anyway. My thing is that I listen to a lot of Steve Vai (he's the bestest!11!! lol) and so when I approach a lead tone it usually has a phat (yes, with a PH) mid-driven sound. Not too much that it sounds honky, but just enough that it makes it nice and round and cuts through with ease. Whereas my rhythm guitars tend to have a good amount of mids but I tame them later with post eq in the box. I always run Rcomp on leads, and get kinda generous on it when it comes to shredders that way when they are doing their thing on the low strings the notes don't disappear under the rhythm guitars.
Sometimes I'll even get a great rhythm sound that has too much mids in it *only* when there are leads on top, so I'll end up automating the EQ to scoop some mids during the solo(s)/lead(s).
All in all it's a safe bet to start off treating leads like vocals. That's what I've learned anyway.
~e.a
, try using the U67 mic model when you do the leads. Another tip is to use a different amp than the rhythm guitars are using, but that's something you probably knew already. 
