Been doing a hardware version of this on my session today.
Trace Elliot Combo with 15" speaker for the clean low's, mic'd with a E602 and a CAD M179
Ibanez TS7 into a Hartke Head with a Trace Elliot 4x10" Cab for the distored mids and high's, mic'd with a I5 and a SM7B
Bass is a Marett with soapbar pickups (no I've never heard of it either! sounds decent enough though)
Probably wont use all 4 mic's in the mix, just nice to have options.
Also grabbed a DI as a backup.
If it comes out good I might post a clip.