For a truly tight guitar tone, I'd recommend running a Les Paul custom with EMG's (81's or 85's -- your preference) in 18v mode into a Maxon OD820 or a TC Line Driver, then into a JCM800 with an extra gain stage, then through a THD Hot Plate and into a Krank Revolution cab.
Then send the Hot Plate signal through a laptop running the Waves C4 plugin with Andy's preset into the power amp in of a 5150 (with the master gain on 6) into a Dual Recto cab.
But wait, you're not done yet, crunchmaster! Place the two cabs facing eachother at a 3:1 ratio distance from the Royer R-121 that you're gonna put between them. Don't worry, the latency of the laptop send will prevent any phase problems. Run the signal from the R-121 into a Manley Slam!, then through the house PA. Or just bring your own.
Now it's time to build the ISO booth! You're gonna have to do some research on this, since this is an unprecedented tight guitar tone endeavor. But first you'll need to send out an expedition to locate a suitable supply of Owens Corning 703, aged Brazilian rosewood, and clay tiles from an Aztec temple (Incan will do in a pinch) just to get a head start.
For reading, I would suggest the usual acoustic texturing drivel, of course, as well as some magnetic theory (even though nobody really understands that anyway), quantum mechanics, microbiology, astronomy, astrology, and air purification and pressurization.
You might also want to brush up on your relativity in case you need to lay down some tracks on a spaceship when you're collected by beings of higher intelligence because the paradoxical blend of unparalled tightness and earth shattering crunch of your tone caused a rift in the space-time continuum.
Please post some .mp3's when you're done. Thanks!