I feel the overwhelming desire to proceed to start laying into Fallout 3 for being one of the worst games ever made since you mentioned it.
Borderlands actually looks like it's had some level of quality control and effort put into its game world and gameplay mechanics, Fallout 3 felt like it was put together in 5 minutes by a 5 year old and a set of Oblivion mod tools.
Fallout 3 doesn't have cool scripted events and epic moments, story telling or character development, and it sure as hell doesn't have any moral choices that have any PROPER reprocussions. Fuck FO3.
However, Mass Effect is the shit and everyone should buy it 6 times over so bioware gets lots of money for all their hard work because they're good boys.
And anyway on the subject of Borderlands, yeah it looks pretty fucking cool but Gearbox Software's president Randy Pitchford makes me want to hurt things. He's just so infuriatingly irritating. During all the E3 gameplay demos for the Brothers In Arms series he repeats the same fucking bullshit marketing lines about how "I can ACTUALLY (emphasis on actually) move my squad over to that wall, and tell them to suppress that german firetime" and then some Colonel cunt who just happens to sit around at Gearbox drinking all their coffee while Gearbox make awful WWII games goes "hooah, nice shot!" to boost the cunts ego now and then.
This alone has made me not want to buy Borderlands. But yeah I'll be giving it a look. This might be one of the few games I download before I buy seeing as there's no demo (or at least I don't think there is) and I'm truly on the fence about it.