Awesome, thanks for all the recs guys.
I'm not sure I know exactly what I'm asking for beyond "sci-fi horror set on a spaceship." Caliban scratched the itch pretty well, really enjoyed the story. I only wish the setup was a bit longer; I'd have loved to get more of the characters simply living on a spaceship way out in the big nothing, and the quiet horrors that accompany that isolation, before the major action started. But the action was great, so I'm not complaining. In terms beyond comics, movies like Alien and Event Horizon get somewhat at what I'm into. For B movies, Creature and Dead Space (1991), although I much prefer the Scott and P.T. Anderson films.
I read some of the Alien series comics when I was younger, loved them and would love to revisit them.
I don't spend too much time with comics but recently just found myself hungry for something in the graphic medium that fell somewhat in this camp, which is why I asked. I'm open to series or graphic novels that take various approaches, so any and all recs are welcome. I'll try to work my way through the titles you both mentioned, probably start with Southern Cross.