My vote clearly goes to SIMPSONS!!!!!!!!!!!!!!!!!!
When I first saw South Park I thought it was alright, but then I quickly got tired of it, as it's the same jokes over and over again I think. "Shut the fuck up, stupid fucker" and so on and so on. If I start watching it regularly I might find it better, but then I could just as well start watching "The nanny" as I'd be able to find funny stuff in that somewhere too.
By the way, I haven't seen any of the other nominees.
Shows I could have used in the poll:
Futurama & Family Guy