My current live setup is two Edwards guitars and occasionally my J-custom Ibanez, when I don't have to travel with it.
Previously, I used two 5150 heads through a BBE sonic maximizer and a Rocktron Xpressions (for the Hush and stereo split) into a full stack of Marshalls... that is until I discovered the Savage 120.
The Savage has a waaay bigger sound even through 1 cab than the two 5150's ever had. For live sound at least. That being said... I still use the 5150 for recording all the time.
PS When I get to play a big enough venue, X2 wireless.