The Colts defense is weakest against the run. New England has no run to speak of.
New Englands pass rush is nonexistant, they never got near Steve McNair last week. You can't do that to Peyton Manning. Especially now that he's on this roll. (Two weeks, two perfect games, scoring on almost every possesion.)
If the Colts get to Tom Brady like they did in the last half of the last game the two played from the start it'll be all Colts.