This this this this this.
Intonation is the biggest issue. Second is the issue of insanely thick strings sounding like dogshit.
You guys are right, I didn't intend to say it that "harsh". But to be honest, I've not encountered huge intonation problems at shorter scales, atleast when tuning to somewhat reasonable pitch (let's say, not any lower than A, anything below that is Djent-Territory), and I'm very anal about tuning usually. It needs some setup for sure, but for something like drop C or B, a 24.75 is still totally ok if you stick with like a 56 on the C-string for example. I'd say a Gibson LP with an EMG 81 and a 56 set tuned to C should result in a rather awesome tone. I'm generally not a fan of tuning lower than B though, it just doesn't sound like a guitar anymore.
@ Keregioz: Tuning stability is basically 100% your bridge and nut. If the string are well stretched, the "give" of the material in conjunction with how easy the strings "slip" dictates the tuning stability (atleast on a regular, well-build guitar that is, if the neck doesn't hold up you might aswell throw the guitar out the window). You can actually lube your nut (no faggotry intended) and I will increase tuning stability vastly.
A string with higher tension will always stay in pitch far better, there is just less movement there.
We really need a thread like "preparing guitars for tracking", since guitarists are mostly retards who believe in magic powers when it comes to the quality and setup of the actual instrument
.