In the case of running it into a Toneport, which is an audio interface, the only thing it will be cutting off when the gate closes is any inherent self-noise in your guitar's electronics. I use an ISP Decimator in my own guitar rig and can tell you that at higher settings it will reduce the output of your guitar, thereby decreasing how hard you're hitting the front end of the Line 6's emulation software. Net effect: Higher settings on a Decimator in your setup will result in less distortion, especially in your preamp stage.