What type of ISP is it? If its the G-string, you want to run it through the FX loop because its not doing anything if it isn't plugged into the FX. Like everyone else said, it needs to be after your OD pedal. You need to turn up the threshold so that feedback is eliminated. If you are still having feedback on maximum settings and you are not playing that loud, I thing you might want to turn down your gain on the amp becuase seriously, turning up the gain all the way to 11 is for beginners.