general tips:
- turn off the gate, it may be helfpul but try to dial in a sound that does not require a gate
- keep the gain low
- keep patches as simple as possible
amp block tips:
- keep the "boost" off, except you are using a model that does not have enough gain
- keep the "bright" switch off, if your tone is too dark, lover the bass!
- keep the bass low in general, also you can work with rather extreme low cut options, then add bass afterwards to get some more ballls
- in the advanced options keep depth at "0", the higher you go the mudier the sound gets
- turn "damp" up, turn "sag" down, this helps to get more bite/definition. do not turn "sag" too much 2-3 should be perfect.
- leave "warmth" and "thump" down, may be good for blues but not for crushing metal tones.
- just as in real life you can use a TS808 to boost some mids, just leave the gain at "0" and turn up the "tone" high settings may sound nasal, i have it set to 6-7
- use low cut/hi cut settings to ger rid of unwanted frequencies. the axe has about 10000 places where you can set hi/low cuts, i haven't found the one setting where it works the best but i often set it in the drive (TS808) block
cab block tips:
- find a good IR!

- i could upload some good free IR's i've collected in the past few years btw, just let me know
hope this helps a bit!
cheers
S.