Not really metal, but King's X's "Dogman" is a Strat into a rackmount Recto. Heavy tones for sure.
IIRC, the chain was Strat --> Dual "Racktifier" --> slaved to Mesa Simul 395 power amps --> Mesa 4x12s w/Vintage 30s.
Aside from that, I remember Dave Mustaine saying he used a Strat for some overdubs on one of the more recent Megadeth records- The World Needs A Hero, I think.
I saw Kovenant live with Moonspell and Amorphis a few years ago. They were using single-coil Strats.
I've seen live shots of Mikael Akerfeldt from Opeth with a Strat as well. I know they use them in the studio for clean stuff on occasion.
Probably not the most metal example, but Kirk Hammett used a single coil Strat a fair bit on Reload. Not a great album by any stretch, but killer tones and production.
I know a lot of guys use 'em for clean stuff (myself included!) but they don't get a ton of use for heavy rhythms. I should cut some heavy tracks with my Strat; it is a cool tone if it's dialed in right- really biting and agressive.