the way i see it, the more analog shit you can throw into the signal chain before hitting digital processing, the better off you'll be
that doesn't mean you wanna run your shit through 20 crap pedals and muck up the source signal, but squeeze as much as your tone as possible from analog shit
i don't have a POD, and do my emulation shit w/ amplitube, and have found that the best DI tone i can get is from using my ART MPA gold, and pushing the tube input just hard enough to get some saturation, sometimes even a teeny bit of audible distortion.