I have a Laney TF300 combo. I have my GT8 hooked up to it using the 4 cable method aswell. I haven't altered the Fx chain settings at all. I've been able to get great tones without going near the Fx chain, however, in the last few days i've been trying to set up the pedal bend effect, the same as a whammy pedal. I cannot get it to sound right at all so i've had to tweak the Fx chain order quite a bit. Still no luck though.