I think it's more complex than that because you are dealing with several issues including standing waves, the resonant frequency of the chamber, the resonant frequency of the cabinet itself etc. Obviously these factors vary greatly on what you are trying to do. In the instance of the randall style iso cab you also have the issue of the speaker cabinet section and the "room section" (the part with the mic) actually physically sharing 4 walls and all of their resonances. I don't know what the implications of that are.
I believe to make a 4x12" iso cab using the golden ratio it would have to be around 11' long at which point you're just building a room. These issues and the lack of need for true isolation are what lead me to the "soft room" approach. Non parallel walls and tons of insulation help but unless you have serious money and space to invest you are trading problems rather than solving them.