I was thinking, with the standing waves issue and box size, you could build a false wall out of some 705 and suspend it in a deadzone with floor isolators, with the space between the false wall and the box itself, you could absorb the lows and and even get rid of standing waves even though you have a square box. You could take it a step further and leave open room at the opposite wall from the speaker and run a labyrinth up and across the entire top of the box lined with cellulose or more 705.
Something like this:
Basically you would have a large Isobox with a floating room within it being made out of bass traps, if the density of the 705 is thick enough to absorb low frequencies, you remove the boxiness, then adding the oversize vent allows the depressurization with minimal volume as there would be more surface area for the 705 to absorb. Due to the deadspace you would not need as much space inside the isobox relative to its performance.
The sketch is just a side dissection with no bracing design, something of that sort would have to be done with a cad program or Sketchup, I was merely throwing the idea out there.