I'm a big fan of the "weird" observational comics... Zach Galifianakis, Demetri Martin, Louis C.K., Maria Bamford, Jimmy Carr, Jim Gaffigan... these are some of the comics who have been on my radar a lot lately. Some other current faves are Lewis Black, Patton Oswalt, Ron White, Bonnie McFarlane, Brian Posehn (the "Metal By Numbers" guy), Pablo Francisco, Louis Ramey, and I'm sure there are plenty I'm missing.
Of course, I'll always love the all-time geniuses: Bill Hicks (RIP), George Carlin, Richard Jeni (RIP), Jeff Foxworthy, Bill Engvall, Denis Leary, Steven Wright, Eddie Murphy, etc.