You know 3/4 of you guys are fucking tards right ......lol
Ok here is the BOTTOM LINE on the Saffire vs the M-Audio.....
Saffire = Cleaner pre's more latency by about 1.5ms when set up properly with the latest drivers. Any of you idiots say you can hear 1.5 ms latency is a fucking retard, and you probably claim to have a 15 inch pecker too. Less driver issues then the M-Audio. MUCH more routing functionality then the M-Audio.
M-Audio = Not as good pre's but still good, and still better then the DIGI. Less latency then the Saffire, not as many routing options, more drivers issues then Saffire.
So it comes down to this, if you need cleaner pre's and more routing to external gear go with the Saffire. If you dont need the routing and dont mind dealing with driver issues get a Profire.
This is not bias, its FACT. Ask any Saffire owner on this board if they have driver issues. Then ask any M-Audio user. I am willing to bet $100 that the pro fire users have WAYYYY more issues then us Saffire users.
Now that being said ...
I own a Pro 40 and I will probably never change to another interface in my life. The Pre's are 100% transparent to my ears, I can re-amp with out a re-amp box without any issues, and the driver stability has been PERFECT in XP, Win7, and Vista. I cant comment on Mac drivers because I don't own one.
Finally ... who in their right mind records drums with the samples on to as they record. That's just pointless, and a waste of CPU and can just lead to problems. Ermin .... I love you dude, but I call bullshit on this man. Why in the living fuck would you track drums with the samples running and monitor it that way in the DAW? What if a sample mis-triggers and you dont notice it? You telling me you go back afterward and fix all that shit ... WHY! Record the drums listen to the natural drum sound and you can re-do whatever needs fixing. Thats ALOT easier then trying to edit shit later on.