Romeo is currently using Line 6 Vetta amp. The same technology is employed on the PODxt so you can be cheap there. If $400 is cheap for you, anyway!
Pickups: Romeo is using Dimarzio X2N for a bridge pickup and Tone Zone for the neck.
His guitars are ESP MII Deluxe's (No longer made, closest stuff: ESP LTD DELUXE M2000, unless you order a custom shop piece. The MII was mahogany, tho... :/ ).
Make sure your style can push around this ton of midrange DiMarzios generally produce, especially with Mesa/Boogie amps. Romeo's tones are generally based on the Mark IIc+ Boogie.
Now that's for the exact sound.
My suggestion: Buy a guitar that is actually descent (say, a Yamaha RGX420) and some amp modeler (say, a Digitech RP300) and THEN think if you need to be THAT pro.
You won't hear the difference if MJR played my suggestion or his rig. At least not unless you A/B them, try 'em in a mix, e.t.c..
Like YJM would say "Play with your ears".
(I love that advice!)