I usually have trouble getting the guitars to meld well in the mix when they are software amp'd guitars. There something about a real guitar amp that just makes it sit in the mix much better, I think it's because software guitar amps have some weird sort of nasally thing going on in the mid-range and it goes harmonically through almost the entire frequency range. But I have found that usually cutting the mid-range (especially 1KHz) on ITB guitars will make them sit better in the mix.