Depends, do you want one that concentrates on the Joey B. era, or both Joey and John Bush?
If you don't consider 2 discs to be "massive", Anthrology: No Hit Wonders (1985-1991) is a great compilation of the early years.
If yo're just looking for a one-disc best-of, Madhouse:The Very Best Of Anthrax is OK, even though the band doesn't endorse it.
If you want one that covers Joey and John eras, Return Of The Killer A's is great!
Good luck!